Research :: Denticious 5000

Elevated fluoride products enhance remineralization of advanced enamel lesions.

ten Cate JM, Buijs MJ, Miller CC, Exterkate RA.

Cariology/Endodontology/Pedodontology, Academic Center for Dentistry (ACTA), Louwesweg 1, 1066 EA Amsterdam, The Netherlands. jm.ten.cate@acta.nl

Caries prevention might benefit from the use of toothpastes containing over 1500 ppm F. With few clinical studies available, the aim of this pH-cycling study was to investigate the dose response between 0 and 5000 ppm F of de- and remineralization of advanced (> 150 microm) enamel lesions. Treatments included sodium and amine fluoride, and a fluoride-free control. Mineral uptake and loss were assessed from solution calcium changes and microradiographs. Treatments with 5000 ppm F both significantly enhanced remineralization and inhibited demineralization when compared with treatments with 1500 ppm F. Slight differences in favor of amine fluoride over sodium fluoride were observed. The ratio of de- over remineralization rates decreased from 13.8 to 2.1 in the range 0 to 5000 ppm F. As much as 71 (6)% of the remineralized mineral was calculated to be resistant to dissolution during subsequent demineralization periods. With 5000-ppm-F treatments, more demineralizing episodes per day (10 vs. 2 for placebo) would still be repaired by remineralization.

PMID: 18809748 [PubMed - indexed for MEDLINE 1: Compend Contin Educ Dent. 1997 Dec;18(12):1238-40. Links

The effect of sodium lauryl sulfate on recurrent aphthous ulcers: a clinical study.

Chahine L, Sempson N, Wagoner C.

This study measured the incidence of recurrent aphthous ulcers during the use of dentifrices with and without sodium lauryl sulfate (SLS). A single-blind, crossover design was used. A statistically significant reduction in recurrent aphthous ulcers was observed during 2 months' use of SLS-free dentifrice compared to 2 months' use of the SLS-containing dentifrice. These results support the results of an earlier independent study, and suggest that use of an SLS-free dentifrice should be considered for individuals suffering from recurrent aphthous ulcers.

PMID: 9656847 [PubMed - indexed for MEDLINE]Wiley InterScience

1: Am J Dent. 2000 Aug;13(4):218-20. Links

Effectiveness of two fluoride dentifrices to arrest root carious lesions.

Lynch E, Baysan A, Ellwood R, Davies R, Petersson L, Borsboom P.

Dental School, Royal Victoria Hospital, Queen's University, Belfast, Northern Ireland, United Kingdom. e.lynch@mds.qmw.ac.uk

PURPOSE: To compare the effectiveness of Prevident 5000 Plus (5,000 ppm F) and Colgate Winterfresh Gel (1100 ppm F) to arrest root carious lesions. MATERIALS AND METHODS: 201 subjects with at least one root carious lesion were recruited from dental school patients. They were randomly assigned to use either Prevident 5000 Plus (5000 ppm F) or Colgate Winterfresh Gel (1100 ppm F) as sodium fluoride in the same silica base. Measurements of lesion hardness, area, distance from the gingival margin, cavitation and plaque were recorded at baseline and after 3 months by a single examiner. RESULTS: After 3 months 38% of subjects using Prevident 5000 Plus and 10% using Winterfresh Gel had one or more lesions that had become hard (P < 0.001). Non-cavitated lesions at baseline were more likely to become hard than cavitated lesions. Compared to the Winterfresh group there was significant increase in the distance from the base of the lesion to the gingival margin and plaque scores were reduced in those using Prevident 5000 Plus.

PMID: 11763936 [PubMed - indexed for MEDLINE

: Am J Dent. 2007 Aug;20(4):212-6. Links

Effect of dentifrice containing 5000 ppm fluoride on non-cavitated fissure carious lesions in vivo after 2 weeks.

Schirrmeister JF, Gebrande JP, Altenburger MJ, Mönting JS, Hellwig E.

Department of Operative Dentistry and Periodontology, Albert-Ludwigs-University Freiburg, Germany. joerg.schirrmeister@uniklinik-freiburg.de

PURPOSE: This randomized clinical trial compared the ability of two dentifrices, one containing 5000 ppm fluoride (Duraphat) and the other 1450 ppm fluoride (Caries Protection, control) to reverse non-cavitated fissure carious lesions. METHODS: 30 adults having occlusal lesions with DIAGNOdent values between 10 and 20 were randomly assigned to two groups of 15 participants each. DIAGNOdent measurements were performed after cleaning the teeth with cleaning brushes and after additional cleaning using an airflow device. The participants were instructed to brush their teeth three times a day for 3 minutes after the meals with a 2 cm line of their assigned dentifrice. After a period of 2 weeks, the teeth were cleaned again with the airflow device and laser fluorescence measurement was performed. RESULTS: The group using the dentifrice containing 5000 ppm showed a significantly higher decrease in laser fluorescence (21%) over the test period than the control group (4%; P< 0.001; repeated measures ANOVA). The decrease in laser fluorescence in the test group was significant (P< 0.001; Wilcoxon signed-rank test). The difference between cleaning the teeth with cleaning brushes and additional cleaning with airflow before DIAGNOdent measurement was not statistically different (P> 0.05; Wilcoxon signed-rank test).

PMID: 17907481 [PubMed - indexed for MEDLINE